BindingDB PrimarySearch

BDBM85095 CAS_151171::CONIVAPTAN::NSC_151171::YM087

SMILES: Cc1nc-2c(CCN(C(=O)c3ccc(NC(=O)c4ccccc4-c4ccccc4)cc3)c3ccccc-23)[nH]1

InChI Key: InChIKey=IKENVDNFQMCRTR-UHFFFAOYSA-N

Data: 12 KI 2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 85095
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
AVPR1A (RAT)	BDBM85095 (CAS_151171 \| CONIVAPTAN \| NSC_151171 \| YM087) Show SMILES Show InChI	Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase DrugBank PC cid PC sid UniChem Patents Similars	PubMed	0.240	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Yamanouchi Pharmaceutical Co., Ltd Curated by PDSP K_i Database									J Pharmacol Exp Ther 282: 301-8 (1997) BindingDB Entry DOI: 10.7270/Q25T3J1N
					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Homo sapiens (Human))	BDBM85095 (CAS_151171 \| CONIVAPTAN \| NSC_151171 \| YM087) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	0.360	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Displacement [3H]Arg human recombinant Vasopressin V2 receptor				Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin V2 Receptor (Rattus norvegicus (Rat))	BDBM85095 (CAS_151171 \| CONIVAPTAN \| NSC_151171 \| YM087) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase DrugBank PC cid PC sid UniChem Patents Similars	PubMed	0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Yamanouchi Pharmaceutical Co., Ltd Curated by PDSP K_i Database									J Pharmacol Exp Ther 282: 301-8 (1997) BindingDB Entry DOI: 10.7270/Q25T3J1N
					More data for this Ligand-Target Pair
Vasopressin V1a receptor (Homo sapiens (Human))	BDBM85095 (CAS_151171 \| CONIVAPTAN \| NSC_151171 \| YM087) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	0.430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Displacement [3H]Arg human recombinant Vasopressin V1a receptor				Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair
AVPR1A (RAT)	BDBM85095 (CAS_151171 \| CONIVAPTAN \| NSC_151171 \| YM087) Show SMILES Show InChI	Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase DrugBank PC cid PC sid UniChem Patents Similars	PubMed	0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Yamanouchi Pharmaceutical Co., Ltd Curated by PDSP K_i Database									J Pharmacol Exp Ther 282: 301-8 (1997) BindingDB Entry DOI: 10.7270/Q25T3J1N
					More data for this Ligand-Target Pair
Vasopressin receptor (RAT)	BDBM85095 (CAS_151171 \| CONIVAPTAN \| NSC_151171 \| YM087) Show SMILES Show InChI	Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
UMR7200 CNRS/Universit£ de Strasbourg Curated by ChEMBL					Assay Description Displacement of [3H]AVP from V1A receptor in Wistar rat liver membranes incubated for 60 mins by microplate scintillation counting method				J Med Chem 61: 8670-8692 (2018) Article DOI: 10.1021/acs.jmedchem.8b00697 BindingDB Entry DOI: 10.7270/Q24J0HRF
UMR7200 CNRS/Universit£ de Strasbourg Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin receptor (Rattus norvegicus (Rat))	BDBM85095 (CAS_151171 \| CONIVAPTAN \| NSC_151171 \| YM087) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
UMR7200 CNRS/Universit£ de Strasbourg Curated by ChEMBL					Assay Description Displacement of [3H]AVP from V2 receptor in Wistar rat kidney membranes incubated for 60 mins by microplate scintillation counting method				J Med Chem 61: 8670-8692 (2018) Article DOI: 10.1021/acs.jmedchem.8b00697 BindingDB Entry DOI: 10.7270/Q24J0HRF
UMR7200 CNRS/Universit£ de Strasbourg Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin V2 Receptor (Rattus norvegicus (Rat))	BDBM85095 (CAS_151171 \| CONIVAPTAN \| NSC_151171 \| YM087) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase DrugBank PC cid PC sid UniChem Patents Similars	PubMed	3.04	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Yamanouchi Pharmaceutical Co., Ltd Curated by PDSP K_i Database									J Pharmacol Exp Ther 282: 301-8 (1997) BindingDB Entry DOI: 10.7270/Q25T3J1N
					More data for this Ligand-Target Pair
Oxytocin receptor (RAT)	BDBM85095 (CAS_151171 \| CONIVAPTAN \| NSC_151171 \| YM087) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	44	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
UMR7200 CNRS/Universit£ de Strasbourg Curated by ChEMBL					Assay Description Displacement of [3H]OT from OTR in Wistar rat uterus membranes incubated for 60 mins by microplate scintillation counting method				J Med Chem 61: 8670-8692 (2018) Article DOI: 10.1021/acs.jmedchem.8b00697 BindingDB Entry DOI: 10.7270/Q24J0HRF
UMR7200 CNRS/Universit£ de Strasbourg Curated by ChEMBL					More data for this Ligand-Target Pair
Oxytocin receptor (RAT)	BDBM85095 (CAS_151171 \| CONIVAPTAN \| NSC_151171 \| YM087) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase DrugBank PC cid PC sid UniChem Patents Similars	PubMed	44.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Yamanouchi Pharmaceutical Co., Ltd Curated by PDSP K_i Database									J Pharmacol Exp Ther 282: 301-8 (1997) BindingDB Entry DOI: 10.7270/Q25T3J1N
					More data for this Ligand-Target Pair
Vasopressin receptor (RAT)	BDBM85095 (CAS_151171 \| CONIVAPTAN \| NSC_151171 \| YM087) Show SMILES Show InChI	Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase DrugBank PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Yamanouchi Pharmaceutical Co., Ltd Curated by PDSP K_i Database									J Pharmacol Exp Ther 282: 301-8 (1997) BindingDB Entry DOI: 10.7270/Q25T3J1N
					More data for this Ligand-Target Pair
Vasopressin receptor (RAT)	BDBM85095 (CAS_151171 \| CONIVAPTAN \| NSC_151171 \| YM087) Show SMILES Show InChI	Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
UMR7200 CNRS/Universit£ de Strasbourg Curated by ChEMBL					Assay Description Displacement of [3H]AVP from V1B receptor in Wistar rat pituitary membranes incubated for 60 mins by microplate scintillation counting method				J Med Chem 61: 8670-8692 (2018) Article DOI: 10.1021/acs.jmedchem.8b00697 BindingDB Entry DOI: 10.7270/Q24J0HRF
UMR7200 CNRS/Universit£ de Strasbourg Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin V2 receptor (Homo sapiens (Human))	BDBM85095 (CAS_151171 \| CONIVAPTAN \| NSC_151171 \| YM087) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Antagonist activity at human Vasopressin 2 receptor assessed as inhibition of intracellular cAMP accumulation				Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Vasopressin V1a receptor (Homo sapiens (Human))	BDBM85095 (CAS_151171 \| CONIVAPTAN \| NSC_151171 \| YM087) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Antagonist activity at human Vasopressin V1a receptor assessed as inhibition of intracellular calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 20: 3742-5 (2010) Article DOI: 10.1016/j.bmcl.2010.04.068 BindingDB Entry DOI: 10.7270/Q24F1QW2
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair