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BDBM50320269 (R)-1-(1-cyclopropyl-2-methoxyethyl)-5-(6-methoxy-2-(trifluoromethyl)pyridin-3-ylamino)-3-methyl-1,2,4-triazin-6(1H)-one::CHEMBL1082358

SMILES: COC[C@@H](C1CC1)n1nc(C)nc(Nc2ccc(OC)nc2C(F)(F)F)c1=O

InChI Key: InChIKey=YFXUIKYIQHGCCE-LBPRGKRZSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50320269   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))		BDBM50320269
PNG
((R)-1-(1-cyclopropyl-2-methoxyethyl)-5-(6-methoxy-...)
Show SMILES COC[C@@H](C1CC1)n1nc(C)nc(Nc2ccc(OC)nc2C(F)(F)F)c1=O
Show InChI InChI=1S/C17H20F3N5O3/c1-9-21-15(16(26)25(24-9)12(8-27-2)10-4-5-10)22-11-6-7-13(28-3)23-14(11)17(18,19)20/h6-7,10,12H,4-5,8H2,1-3H3,(H,21,22,24)/t12-/m0/s1
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Article
PubMed
n/an/a 2.30n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-ovine CRF from rat CRF1 receptor

Bioorg Med Chem Lett 20: 3579-83 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.121
BindingDB Entry DOI: 10.7270/Q2SX6DDP
More data for this
Ligand-Target Pair