BDBM50321053 CHEMBL1163559::{4-[1-(5-Chloro-2-trifluoromethyl-benzyl)-1,2,3,4-tetrahydro-pyrido[2,3-b]pyrazin-7-yl]-phenyl}-(4-pyrrolidin-1-ylpiperidin-1-yl)-methanone

SMILES FC(F)(F)c1ccc(Cl)cc1CN1CCNc2ncc(cc12)-c1ccc(cc1)C(=O)N1CCC(CC1)N1CCCC1

InChI Key InChIKey=JVVGHVJDZJSKRA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50321053   

TargetALK tyrosine kinase receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50321053({4-[1-(5-Chloro-2-trifluoromethyl-benzyl)-1,2,3,4-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of ALK by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50321053({4-[1-(5-Chloro-2-trifluoromethyl-benzyl)-1,2,3,4-...)
Affinity DataIC50: 250nMAssay Description:Inhibition of ALK phosphorylation in human Karpas-299 cells by immunoblotting and ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed