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BDBM50322143 3-(4-chlorophenylsulfonyl)-N-(2,3-dimethylphenyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine::CHEMBL1170687

SMILES: Cc1cccc(Nc2nc3c(nnn3c3ccsc23)S(=O)(=O)c2ccc(Cl)cc2)c1C

InChI Key: InChIKey=KWSRBKUWEMKUOG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50322143   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50322143
PNG
(3-(4-chlorophenylsulfonyl)-N-(2,3-dimethylphenyl)t...)
Show SMILES Cc1cccc(Nc2nc3c(nnn3c3ccsc23)S(=O)(=O)c2ccc(Cl)cc2)c1C
Show InChI InChI=1S/C21H16ClN5O2S2/c1-12-4-3-5-16(13(12)2)23-19-18-17(10-11-30-18)27-20(24-19)21(25-26-27)31(28,29)15-8-6-14(22)7-9-15/h3-11H,1-2H3,(H,23,24)
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Article
PubMed
n/an/a 800n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production


Bioorg Med Chem 18: 5282-90 (2010)


Article DOI: 10.1016/j.bmc.2010.05.051
BindingDB Entry DOI: 10.7270/Q2F190QT
More data for this
Ligand-Target Pair