BDBM50323089 9-(3-(dimethylamino)propyl)-2-(4-ethoxy-3-(trifluoromethyl)phenyl)-9H-purine-6-carbonitrile::CHEMBL1209534

SMILES CCOc1ccc(cc1C(F)(F)F)-c1nc(C#N)c2ncn(CCCN(C)C)c2n1

InChI Key InChIKey=UHFLVCRUHSLCAK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50323089   

TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323089(9-(3-(dimethylamino)propyl)-2-(4-ethoxy-3-(trifluo...)
Affinity DataIC50:  59nMAssay Description:inhibition of cathepsin S in human JY cells assessed as Lip10 accumulation by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323089(9-(3-(dimethylamino)propyl)-2-(4-ethoxy-3-(trifluo...)
Affinity DataIC50:  117nMAssay Description:Inhibition of human recombinant cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323089(9-(3-(dimethylamino)propyl)-2-(4-ethoxy-3-(trifluo...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of human recombinant cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed