BDBM50323097 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(2-hydroxyethylamino)pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1208963

SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NCCO)c1)c1ccccc1Cl

InChI Key InChIKey=ASTXNDZZOAPTNR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50323097   

TargetSerine/threonine-protein kinase PLK1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50323097((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(2-hydrox...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PLK1 by SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50323097((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(2-hydrox...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant CYP2C9 using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50323097((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(2-hydrox...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human recombinant CYP3A4 using 7-benzyloxyquinoline as substrate by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed