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BDBM50323118 (R)-5-(5-(pyridin-2-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1209756

SMILES: C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccccn1)c1ccccc1C(F)(F)F

InChI Key: InChIKey=GDMBPOYBSJXINX-GGYSOQFKNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50323118   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PLK3


(Homo sapiens (Human))
BDBM50323118
PNG
((R)-5-(5-(pyridin-2-yl)-1H-benzo[d]imidazol-1-yl)-...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccccn1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C26H19F3N4O2S/c1-15(17-6-2-3-7-18(17)26(27,28)29)35-22-13-23(36-24(22)25(30)34)33-14-32-20-12-16(9-10-21(20)33)19-8-4-5-11-31-19/h2-15H,1H3,(H2,30,34)/t15-/s2
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 79n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full lungth PLK3 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50323118
PNG
((R)-5-(5-(pyridin-2-yl)-1H-benzo[d]imidazol-1-yl)-...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccccn1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C26H19F3N4O2S/c1-15(17-6-2-3-7-18(17)26(27,28)29)35-22-13-23(36-24(22)25(30)34)33-14-32-20-12-16(9-10-21(20)33)19-8-4-5-11-31-19/h2-15H,1H3,(H2,30,34)/t15-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PLK1 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair