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BDBM50324337 2'-Cyclohexylamino-6-((R)-3-methylpiperazin-1-yl)[2,4']bipyridinyl-4-carboxylic Acid Amide::CHEMBL1215222

SMILES: C[C@@H]1CN(CCN1)c1cc(cc(n1)-c1ccnc(NC2CCCCC2)c1)C(N)=O

InChI Key: InChIKey=SFSGIDJMRRLJFG-GGYSOQFKNA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50324337   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase D1


(Homo sapiens (Human))
BDBM50324337
PNG
(2'-Cyclohexylamino-6-((R)-3-methylpiperazin-1-yl)[...)
Show SMILES C[C@@H]1CN(CCN1)c1cc(cc(n1)-c1ccnc(NC2CCCCC2)c1)C(N)=O
Show InChI InChI=1/C22H30N6O/c1-15-14-28(10-9-24-15)21-13-17(22(23)29)11-19(27-21)16-7-8-25-20(12-16)26-18-5-3-2-4-6-18/h7-8,11-13,15,18,24H,2-6,9-10,14H2,1H3,(H2,23,29)(H,25,26)/t15-/s2
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKD1 by TR-FRET assay


J Med Chem 53: 5422-38 (2010)


Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J
More data for this
Ligand-Target Pair
Polycystin-2


(Homo sapiens (Human))
BDBM50324337
PNG
(2'-Cyclohexylamino-6-((R)-3-methylpiperazin-1-yl)[...)
Show SMILES C[C@@H]1CN(CCN1)c1cc(cc(n1)-c1ccnc(NC2CCCCC2)c1)C(N)=O
Show InChI InChI=1/C22H30N6O/c1-15-14-28(10-9-24-15)21-13-17(22(23)29)11-19(27-21)16-7-8-25-20(12-16)26-18-5-3-2-4-6-18/h7-8,11-13,15,18,24H,2-6,9-10,14H2,1H3,(H2,23,29)(H,25,26)/t15-/s2
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKD2 by TR-FRET assay


J Med Chem 53: 5422-38 (2010)


Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase D1


(Homo sapiens (Human))
BDBM50324337
PNG
(2'-Cyclohexylamino-6-((R)-3-methylpiperazin-1-yl)[...)
Show SMILES C[C@@H]1CN(CCN1)c1cc(cc(n1)-c1ccnc(NC2CCCCC2)c1)C(N)=O
Show InChI InChI=1/C22H30N6O/c1-15-14-28(10-9-24-15)21-13-17(22(23)29)11-19(27-21)16-7-8-25-20(12-16)26-18-5-3-2-4-6-18/h7-8,11-13,15,18,24H,2-6,9-10,14H2,1H3,(H2,23,29)(H,25,26)/t15-/s2
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 679n/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKD1 assessed as inhibition of HDAC5 neuclear export


J Med Chem 53: 5422-38 (2010)


Article DOI: 10.1021/jm100076w
BindingDB Entry DOI: 10.7270/Q2P84C2J
More data for this
Ligand-Target Pair