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BDBM50324424 (E)-4-(2-(4-(carboxymethoxy)styryl)-4-oxoquinazolin-3(4H)-yl)benzoic acid::CHEMBL1215717

SMILES: OC(=O)COc1ccc(\C=C\c2nc3ccccc3c(=O)n2-c2ccc(cc2)C(O)=O)cc1

InChI Key: InChIKey=DKUSTTDXTWBQAU-VGOFMYFVSA-N

Data: 4 IC50

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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50324424   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50324424
PNG
((E)-4-(2-(4-(carboxymethoxy)styryl)-4-oxoquinazoli...)
Show SMILES OC(=O)COc1ccc(\C=C\c2nc3ccccc3c(=O)n2-c2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C25H18N2O6/c28-23(29)15-33-19-12-5-16(6-13-19)7-14-22-26-21-4-2-1-3-20(21)24(30)27(22)18-10-8-17(9-11-18)25(31)32/h1-14H,15H2,(H,28,29)(H,31,32)/b14-7+
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PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...


J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50324424
PNG
((E)-4-(2-(4-(carboxymethoxy)styryl)-4-oxoquinazoli...)
Show SMILES OC(=O)COc1ccc(\C=C\c2nc3ccccc3c(=O)n2-c2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C25H18N2O6/c28-23(29)15-33-19-12-5-16(6-13-19)7-14-22-26-21-4-2-1-3-20(21)24(30)27(22)18-10-8-17(9-11-18)25(31)32/h1-14H,15H2,(H,28,29)(H,31,32)/b14-7+
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n/an/a>3.00E+5n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2A receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...


J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 2/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50324424
PNG
((E)-4-(2-(4-(carboxymethoxy)styryl)-4-oxoquinazoli...)
Show SMILES OC(=O)COc1ccc(\C=C\c2nc3ccccc3c(=O)n2-c2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C25H18N2O6/c28-23(29)15-33-19-12-5-16(6-13-19)7-14-22-26-21-4-2-1-3-20(21)24(30)27(22)18-10-8-17(9-11-18)25(31)32/h1-14H,15H2,(H,28,29)(H,31,32)/b14-7+
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n/an/a>3.00E+5n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...


J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50324424
PNG
((E)-4-(2-(4-(carboxymethoxy)styryl)-4-oxoquinazoli...)
Show SMILES OC(=O)COc1ccc(\C=C\c2nc3ccccc3c(=O)n2-c2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C25H18N2O6/c28-23(29)15-33-19-12-5-16(6-13-19)7-14-22-26-21-4-2-1-3-20(21)24(30)27(22)18-10-8-17(9-11-18)25(31)32/h1-14H,15H2,(H,28,29)(H,31,32)/b14-7+
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n/an/a>3.00E+5n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GLuR1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced current by two-electrode voltag...


J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair