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BDBM50324430 (E)-3-(6-Methoxy-2-(4-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)-benzoic Acid::CHEMBL1215803

SMILES: COc1ccc2nc(\C=C\c3ccc(cc3)[N+]([O-])=O)n(-c3cccc(c3)C(O)=O)c(=O)c2c1

InChI Key: InChIKey=QGELATWZMBBEFM-KPKJPENVSA-N

Data: 4 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50324430   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1


(RAT-Rattus norvegicus (Rat))
BDBM50324430
PNG
((E)-3-(6-Methoxy-2-(4-nitrostyryl)-4-oxoquinazolin...)
Show SMILES COc1ccc2nc(\C=C\c3ccc(cc3)[N+]([O-])=O)n(-c3cccc(c3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(18-4-2-3-16(13-18)24(29)30)22(25-21)12-7-15-5-8-17(9-6-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-7+
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PC sid
UniChem

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Article
PubMed
n/an/a 2.10E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...


J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50324430
PNG
((E)-3-(6-Methoxy-2-(4-nitrostyryl)-4-oxoquinazolin...)
Show SMILES COc1ccc2nc(\C=C\c3ccc(cc3)[N+]([O-])=O)n(-c3cccc(c3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(18-4-2-3-16(13-18)24(29)30)22(25-21)12-7-15-5-8-17(9-6-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-7+
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PC sid
UniChem

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Article
PubMed
n/an/a 2.38E+5n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2A receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...


J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor subunit epsilon 2/zeta 1


(Rattus norvegicus (Rat)-RAT)
BDBM50324430
PNG
((E)-3-(6-Methoxy-2-(4-nitrostyryl)-4-oxoquinazolin...)
Show SMILES COc1ccc2nc(\C=C\c3ccc(cc3)[N+]([O-])=O)n(-c3cccc(c3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(18-4-2-3-16(13-18)24(29)30)22(25-21)12-7-15-5-8-17(9-6-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-7+
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PubMed
n/an/a 2.38E+5n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2B receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...


J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50324430
PNG
((E)-3-(6-Methoxy-2-(4-nitrostyryl)-4-oxoquinazolin...)
Show SMILES COc1ccc2nc(\C=C\c3ccc(cc3)[N+]([O-])=O)n(-c3cccc(c3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(18-4-2-3-16(13-18)24(29)30)22(25-21)12-7-15-5-8-17(9-6-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-7+
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PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant GLuR1 expressed in Xenopus oocytes assessed as inhibition of glutamate-induced current by two-electrode voltag...


J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair