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BDBM50325004 (R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(4-(pyrimidin-5-yl)phenyl)imidazolidine-2,4-dione::CHEMBL1222943

SMILES: COc1ccc2CN(C[C@]3(NC(=O)NC3=O)c3ccc(cc3)-c3cncnc3)C(=O)c2c1

InChI Key: InChIKey=WYDYTZMGSQLLBJ-QHCPKHFHSA-N

Data: 1 KI

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50325004   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))
BDBM50325004
PNG
((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Show SMILES COc1ccc2CN(C[C@]3(NC(=O)NC3=O)c3ccc(cc3)-c3cncnc3)C(=O)c2c1
Show InChI InChI=1S/C23H19N5O4/c1-32-18-7-4-15-11-28(20(29)19(15)8-18)12-23(21(30)26-22(31)27-23)17-5-2-14(3-6-17)16-9-24-13-25-10-16/h2-10,13H,11-12H2,1H3,(H2,26,27,30,31)/t23-/m0/s1
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MMDB

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Similars

Article
PubMed
0.900n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavage


Bioorg Med Chem Lett 20: 5286-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.134
BindingDB Entry DOI: 10.7270/Q26W9B8K
More data for this
Ligand-Target Pair