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BDBM50325410 (S)-4-(6-(4-hydroxypiperidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-N-(pyrrolidin-2-ylmethyl)benzamide::CHEMBL1223139

SMILES: OC1CCN(CC1)c1ccc2ncc(-c3ccc(cc3)C(=O)NC[C@@H]3CCCN3)n2n1

InChI Key: InChIKey=JCNKSZNKQMAUMB-LGWFVXIRNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50325410   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM50325410
PNG
((S)-4-(6-(4-hydroxypiperidin-1-yl)imidazo[1,2-b]py...)
Show SMILES OC1CCN(CC1)c1ccc2ncc(-c3ccc(cc3)C(=O)NC[C@@H]3CCCN3)n2n1
Show InChI InChI=1/C23H28N6O2/c30-19-9-12-28(13-10-19)22-8-7-21-25-15-20(29(21)27-22)16-3-5-17(6-4-16)23(31)26-14-18-2-1-11-24-18/h3-8,15,18-19,24,30H,1-2,9-14H2,(H,26,31)/t18-/s2
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PC cid
PC sid
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Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of purified His-tagged IKK-beta after 15 mins


Bioorg Med Chem Lett 20: 5113-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.026
BindingDB Entry DOI: 10.7270/Q2513ZDM
More data for this
Ligand-Target Pair