BDBM50326061 (E)-4-(2-(4-Bromobenzylthio)-3-(4-fluoro-3-nitrophenyl)acryloyl)benzoic acid::CHEMBL1242482

SMILES OC(=O)c1ccc(cc1)C(=O)C(\SCc1ccc(Br)cc1)=C/c1ccc(F)c(c1)[N+]([O-])=O

InChI Key InChIKey=VTLBOGLRMDPIDX-CIAFOILYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50326061   

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50326061((E)-4-(2-(4-Bromobenzylthio)-3-(4-fluoro-3-nitroph...)
Affinity DataIC50:  500nMAssay Description:Inhibition of BCR/ABL p210 autophosphorylation in human K562 cells after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Temple University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50326061((E)-4-(2-(4-Bromobenzylthio)-3-(4-fluoro-3-nitroph...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of GST-tagged recombinant CDK1 after 20 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50326061((E)-4-(2-(4-Bromobenzylthio)-3-(4-fluoro-3-nitroph...)
Affinity DataIC50:  750nMAssay Description:Inhibition of Bcr-Abl after 20 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Temple University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50326061((E)-4-(2-(4-Bromobenzylthio)-3-(4-fluoro-3-nitroph...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of GST-tagged recombinant PLK1 after 20 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Temple University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50326061((E)-4-(2-(4-Bromobenzylthio)-3-(4-fluoro-3-nitroph...)
Affinity DataIC50:  1.32E+4nMAssay Description:Inhibition of GST-tagged recombinant Src after 20 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Temple University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50326061((E)-4-(2-(4-Bromobenzylthio)-3-(4-fluoro-3-nitroph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ErbB2 by immunoprecipitation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Temple University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50326061((E)-4-(2-(4-Bromobenzylthio)-3-(4-fluoro-3-nitroph...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of EGFR by immunoprecipitation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Temple University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50326061((E)-4-(2-(4-Bromobenzylthio)-3-(4-fluoro-3-nitroph...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of GST-tagged recombinant LynB after 20 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed