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BDBM50326200 3-Chloro-N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)-pyridin-2-yloxy)phenyl)benzamide::CHEMBL1243008

SMILES: CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2cccc(Cl)c2)cc1C

InChI Key: InChIKey=PZVIQPBSJBPATG-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50326200   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase B


(Homo sapiens (Human))
BDBM50326200
PNG
(3-Chloro-N-(3-methyl-4-(3-(2-(methylamino)pyrimidi...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2cccc(Cl)c2)cc1C
Show InChI InChI=1S/C24H20ClN5O2/c1-15-13-18(29-22(31)16-5-3-6-17(25)14-16)8-9-21(15)32-23-19(7-4-11-27-23)20-10-12-28-24(26-2)30-20/h3-14H,1-2H3,(H,29,31)(H,26,28,30)
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PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 430n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Aurora B by HTRF assay


J Med Chem 53: 6368-77 (2010)


Article DOI: 10.1021/jm100394y
BindingDB Entry DOI: 10.7270/Q2C829H0
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50326200
PNG
(3-Chloro-N-(3-methyl-4-(3-(2-(methylamino)pyrimidi...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2cccc(Cl)c2)cc1C
Show InChI InChI=1S/C24H20ClN5O2/c1-15-13-18(29-22(31)16-5-3-6-17(25)14-16)8-9-21(15)32-23-19(7-4-11-27-23)20-10-12-28-24(26-2)30-20/h3-14H,1-2H3,(H,29,31)(H,26,28,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>1.20E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst staining


J Med Chem 53: 6368-77 (2010)


Article DOI: 10.1021/jm100394y
BindingDB Entry DOI: 10.7270/Q2C829H0
More data for this
Ligand-Target Pair