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BDBM50326211 5-Fluoro-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-2-(phenylamino)benzamide::CHEMBL1243265

SMILES: CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2cc(F)ccc2Nc2ccccc2)cc1

InChI Key: InChIKey=NVRFIADOENNEKV-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50326211   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase B


(Homo sapiens (Human))
BDBM50326211
PNG
(5-Fluoro-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)py...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2cc(F)ccc2Nc2ccccc2)cc1
Show InChI InChI=1S/C29H23FN6O2/c1-31-29-33-17-15-26(36-29)23-8-5-16-32-28(23)38-22-12-10-21(11-13-22)35-27(37)24-18-19(30)9-14-25(24)34-20-6-3-2-4-7-20/h2-18,34H,1H3,(H,35,37)(H,31,33,36)
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Similars

Article
PubMed
n/an/an/an/a 20n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst staining


J Med Chem 53: 6368-77 (2010)


Article DOI: 10.1021/jm100394y
BindingDB Entry DOI: 10.7270/Q2C829H0
More data for this
Ligand-Target Pair