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BDBM50326912 3-(8-(2,4-Difluorophenyl)-1-methyl-2-oxo-1,2-dihydropyrido-[3,2-d]pyridazin-3-yl)-4-methylbenzoic acid::CHEMBL1253812

SMILES: Cc1ccc(cc1-c1cc2cnnc(-c3ccc(F)cc3F)c2n(C)c1=O)C(O)=O

InChI Key: InChIKey=RBICVYLACYVHQF-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50326912   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50326912
PNG
(3-(8-(2,4-Difluorophenyl)-1-methyl-2-oxo-1,2-dihyd...)
Show SMILES Cc1ccc(cc1-c1cc2cnnc(-c3ccc(F)cc3F)c2n(C)c1=O)C(O)=O
Show InChI InChI=1S/C22H15F2N3O3/c1-11-3-4-12(22(29)30)7-16(11)17-8-13-10-25-26-19(20(13)27(2)21(17)28)15-6-5-14(23)9-18(15)24/h3-10H,1-2H3,(H,29,30)
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MMDB

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PC cid
PC sid
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Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase


J Med Chem 53: 6398-411 (2010)


Article DOI: 10.1021/jm100567y
BindingDB Entry DOI: 10.7270/Q26973SS
More data for this
Ligand-Target Pair