BindingDB logo
myBDB logout

BDBM50327458 1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)ethyl)hydrazinecarbonyl)indoline-5-carboxylic acid::CHEMBL1257963

InChI string: InChI=1S/C24H25N5O4/c1-13-5-7-19(11-14(13)2)29-22(30)21(16(4)27-29)15(3)25-26-24(33)28-10-9-17-12-18(23(31)32)6-8-20(17)28/h5-8,11-12,27H,9-10H2,1-4H3,(H,26,33)(H,31,32)

SMILES: CC(=NN=C(O)N1CCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O

InChI Key: InChIKey=VZAGRJBLZSKRSI-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50327458   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50327458
PNG
(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)
Show SMILES CC(=NN=C(O)N1CCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O
Show InChI InChI=1S/C24H25N5O4/c1-13-5-7-19(11-14(13)2)29-22(30)21(16(4)27-29)15(3)25-26-24(33)28-10-9-17-12-18(23(31)32)6-8-20(17)28/h5-8,11-12,27H,9-10H2,1-4H3,(H,26,33)(H,31,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 42n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human TPOR expressed in human BaF3 cells


Bioorg Med Chem Lett 20: 5670-2 (2010)

More data for this
Ligand-Target Pair