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BDBM50327689 3-Fluoro-5-(2-(pyridin-2-yl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)benzonitrile::CHEMBL1257274

SMILES: Fc1cc(cc(c1)N1CCc2nc(oc2C1)-c1ccccn1)C#N

InChI Key: InChIKey=FZOHCTHIDYYEKU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50327689   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50327689
PNG
(3-Fluoro-5-(2-(pyridin-2-yl)-6,7-dihydrooxazolo[5,...)
Show SMILES Fc1cc(cc(c1)N1CCc2nc(oc2C1)-c1ccccn1)C#N
Show InChI InChI=1S/C18H13FN4O/c19-13-7-12(10-20)8-14(9-13)23-6-4-15-17(11-23)24-18(22-15)16-3-1-2-5-21-16/h1-3,5,7-9H,4,6,11H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 54n/an/an/an/an/an/a



Sepracor Inc.

Curated by ChEMBL


Assay Description
Modulation of human recombinant mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced response


J Med Chem 53: 7107-18 (2010)


Article DOI: 10.1021/jm100736h
BindingDB Entry DOI: 10.7270/Q20G3KCJ
More data for this
Ligand-Target Pair