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BDBM50328141 6-morpholino-N-(4-(trifluoromethoxy)phenyl)pyrimidin-4-amine::CHEMBL1258472

SMILES: FC(F)(F)Oc1ccc(Nc2cc(ncn2)N2CCOCC2)cc1

InChI Key: InChIKey=HARWPDFZIKWEJT-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50328141   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bcr-Abl


(Homo sapiens (Human))
BDBM50328141
PNG
(6-morpholino-N-(4-(trifluoromethoxy)phenyl)pyrimid...)
Show SMILES FC(F)(F)Oc1ccc(Nc2cc(ncn2)N2CCOCC2)cc1
Show InChI InChI=1S/C15H15F3N4O2/c16-15(17,18)24-12-3-1-11(2-4-12)21-13-9-14(20-10-19-13)22-5-7-23-8-6-22/h1-4,9-10H,5-8H2,(H,19,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

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PC sid
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Similars

Article
PubMed
n/an/an/an/a 1.80E+3n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of Bcr-Abl in mouse BA/F3 cells


J Med Chem 53: 6934-46 (2010)


Article DOI: 10.1021/jm100555f
BindingDB Entry DOI: 10.7270/Q2DJ5FTW
More data for this
Ligand-Target Pair