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BDBM50328425 CHEMBL1257445::N-(4-(6-(pyridin-3-yl)imidazo[1,2-a]pyrazin-8-ylamino)phenyl)benzamide

SMILES: O=C(Nc1ccc(Nc2nc(cn3ccnc23)-c2cccnc2)cc1)c1ccccc1

InChI Key: InChIKey=TUVOCSLEDZZBSS-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50328425   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase A


(Homo sapiens (Human))
BDBM50328425
PNG
(CHEMBL1257445 | N-(4-(6-(pyridin-3-yl)imidazo[1,2-...)
Show SMILES O=C(Nc1ccc(Nc2nc(cn3ccnc23)-c2cccnc2)cc1)c1ccccc1
Show InChI InChI=1S/C24H18N6O/c31-24(17-5-2-1-3-6-17)28-20-10-8-19(9-11-20)27-22-23-26-13-14-30(23)16-21(29-22)18-7-4-12-25-15-18/h1-16H,(H,27,29)(H,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.75E+3n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human aurora A


Bioorg Med Chem Lett 20: 5988-93 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.091
BindingDB Entry DOI: 10.7270/Q2H995D7
More data for this
Ligand-Target Pair