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BDBM50328476 1-(2-(4-(1-(4-fluorophenyl)-5-((2-methyl-2H-tetrazol-5-yl)methyl)-1H-indol-3-yl)piperidin-1-yl)ethyl)imidazolidin-2-one::CHEMBL1259188

SMILES: Cn1nnc(Cc2ccc3n(cc(C4CCN(CCN5CCNC5=O)CC4)c3c2)-c2ccc(F)cc2)n1

InChI Key: InChIKey=FGHKCRNDQSRICR-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50328476   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ADRA1B


(C.H.O.)
BDBM50328476
PNG
(1-(2-(4-(1-(4-fluorophenyl)-5-((2-methyl-2H-tetraz...)
Show SMILES Cn1nnc(Cc2ccc3n(cc(C4CCN(CCN5CCNC5=O)CC4)c3c2)-c2ccc(F)cc2)n1
Show InChI InChI=1S/C27H31FN8O/c1-33-31-26(30-32-33)17-19-2-7-25-23(16-19)24(18-36(25)22-5-3-21(28)4-6-22)20-8-11-34(12-9-20)14-15-35-13-10-29-27(35)37/h2-7,16,18,20H,8-15,17H2,1H3,(H,29,37)
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Similars

Article
PubMed
0.560n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from hamster cloned alpha1b receptor


J Med Chem 53: 7021-34 (2010)


Article DOI: 10.1021/jm100652h
BindingDB Entry DOI: 10.7270/Q20C4W0P
More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50328476
PNG
(1-(2-(4-(1-(4-fluorophenyl)-5-((2-methyl-2H-tetraz...)
Show SMILES Cn1nnc(Cc2ccc3n(cc(C4CCN(CCN5CCNC5=O)CC4)c3c2)-c2ccc(F)cc2)n1
Show InChI InChI=1S/C27H31FN8O/c1-33-31-26(30-32-33)17-19-2-7-25-23(16-19)24(18-36(25)22-5-3-21(28)4-6-22)20-8-11-34(12-9-20)14-15-35-13-10-29-27(35)37/h2-7,16,18,20H,8-15,17H2,1H3,(H,29,37)
KEGG

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CHEMBL
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PC sid
UniChem

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Article
PubMed
0.660n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from bovine cloned alpha1a receptor expressed in BHK cells


J Med Chem 53: 7021-34 (2010)


Article DOI: 10.1021/jm100652h
BindingDB Entry DOI: 10.7270/Q20C4W0P
More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50328476
PNG
(1-(2-(4-(1-(4-fluorophenyl)-5-((2-methyl-2H-tetraz...)
Show SMILES Cn1nnc(Cc2ccc3n(cc(C4CCN(CCN5CCNC5=O)CC4)c3c2)-c2ccc(F)cc2)n1
Show InChI InChI=1S/C27H31FN8O/c1-33-31-26(30-32-33)17-19-2-7-25-23(16-19)24(18-36(25)22-5-3-21(28)4-6-22)20-8-11-34(12-9-20)14-15-35-13-10-29-27(35)37/h2-7,16,18,20H,8-15,17H2,1H3,(H,29,37)
KEGG

UniProtKB/SwissProt

GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.770n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from rat cloned alpha1d receptor


J Med Chem 53: 7021-34 (2010)


Article DOI: 10.1021/jm100652h
BindingDB Entry DOI: 10.7270/Q20C4W0P
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50328476
PNG
(1-(2-(4-(1-(4-fluorophenyl)-5-((2-methyl-2H-tetraz...)
Show SMILES Cn1nnc(Cc2ccc3n(cc(C4CCN(CCN5CCNC5=O)CC4)c3c2)-c2ccc(F)cc2)n1
Show InChI InChI=1S/C27H31FN8O/c1-33-31-26(30-32-33)17-19-2-7-25-23(16-19)24(18-36(25)22-5-3-21(28)4-6-22)20-8-11-34(12-9-20)14-15-35-13-10-29-27(35)37/h2-7,16,18,20H,8-15,17H2,1H3,(H,29,37)
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PC sid
UniChem

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Article
PubMed
2.70n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cells


J Med Chem 53: 7021-34 (2010)


Article DOI: 10.1021/jm100652h
BindingDB Entry DOI: 10.7270/Q20C4W0P
More data for this
Ligand-Target Pair