BDBM50328600 1-(4-(piperazin-1-ylsulfonyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one::CHEMBL1259105

SMILES O=c1ccc2cnc3ccc(cc3c2n1-c1ccc(cc1)S(=O)(=O)N1CCNCC1)-c1cnc2ccccc2c1

InChI Key InChIKey=LPLRXKMTJHBGBG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50328600   

TargetSerine/threonine-protein kinase mTOR(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50328600(1-(4-(piperazin-1-ylsulfonyl)phenyl)-9-(quinolin-3...)
Affinity DataIC50: 239nMAssay Description:Binding affinity to mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Mouse)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50328600(1-(4-(piperazin-1-ylsulfonyl)phenyl)-9-(quinolin-3...)
Affinity DataIC50: 300nMAssay Description:Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed