BDBM50328602 1-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one::CHEMBL1259136

SMILES CN1CCN(Cc2ccc(cc2)-n2c3c(ccc2=O)cnc2ccc(cc32)-c2cnc3ccccc3c2)CC1

InChI Key InChIKey=MLRYKMPLYNACRR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50328602   

TargetSerine/threonine-protein kinase mTOR(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50328602(1-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-9-(qu...)
Affinity DataIC50: 66nMAssay Description:Binding affinity to mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Mouse)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50328602(1-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-9-(qu...)
Affinity DataIC50: 250nMAssay Description:Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed