BDBM50329521 (S)-2-amino-1-methyl-4-phenyl-4-(4-(trifluoromethoxy)phenyl)-1H-imidazol-5(4H)-one::CHEMBL1271451

SMILES CN1C(N)=N[C@@](C1=O)(c1ccccc1)c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=TVFYWSHHVQUWML-INIZCTEOSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50329521   

TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329521((S)-2-amino-1-methyl-4-phenyl-4-(4-(trifluorometho...)
Affinity DataIC50:  1.42E+3nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329521((S)-2-amino-1-methyl-4-phenyl-4-(4-(trifluorometho...)
Affinity DataIC50:  3.16E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329521((S)-2-amino-1-methyl-4-phenyl-4-(4-(trifluorometho...)
Affinity DataIC50:  2.68E+3nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329521((S)-2-amino-1-methyl-4-phenyl-4-(4-(trifluorometho...)
Affinity DataEC50:  810nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed