BDBM50329566 (R)-2-amino-4-(3-(4,4-difluorobut-3-enyloxy)-4-fluorophenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1270436

SMILES [#6]-[#7]-1-[#6](-[#7])=[#7][C@]([#6]-1=O)(c1ccc(-[#8]-[#6](F)F)cc1)c1ccc(F)c(-[#8]-[#6]-[#6]\[#6]=[#6](\F)F)c1

InChI Key InChIKey=LBGKTMHMJXSPFM-OAQYLSRUSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50329566   

TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329566((R)-2-amino-4-(3-(4,4-difluorobut-3-enyloxy)-4-flu...)
Affinity DataEC50:  300nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329566((R)-2-amino-4-(3-(4,4-difluorobut-3-enyloxy)-4-flu...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed