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BDBM50329894 2-chloro-N-(6-(5-fluoro-4-hydroxy-6-methylpyrimidin-2-yl)pyridin-3-yl)acetamide::CHEMBL1269016

SMILES: Cc1nc([nH]c(=O)c1F)-c1ccc(NC(=O)CCl)cn1

InChI Key: InChIKey=UXNNZCZIBVBREP-UHFFFAOYSA-N

Data: 2 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50329894   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50329894
PNG
(2-chloro-N-(6-(5-fluoro-4-hydroxy-6-methylpyrimidi...)
Show SMILES Cc1nc([nH]c(=O)c1F)-c1ccc(NC(=O)CCl)cn1
Show InChI InChI=1S/C12H10ClFN4O2/c1-6-10(14)12(20)18-11(16-6)8-3-2-7(5-15-8)17-9(19)4-13/h2-3,5H,4H2,1H3,(H,17,19)(H,16,18,20)
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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Piramal Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assay


Bioorg Med Chem Lett 20: 6426-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.083
BindingDB Entry DOI: 10.7270/Q2HX1CXM
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50329894
PNG
(2-chloro-N-(6-(5-fluoro-4-hydroxy-6-methylpyrimidi...)
Show SMILES Cc1nc([nH]c(=O)c1F)-c1ccc(NC(=O)CCl)cn1
Show InChI InChI=1S/C12H10ClFN4O2/c1-6-10(14)12(20)18-11(16-6)8-3-2-7(5-15-8)17-9(19)4-13/h2-3,5H,4H2,1H3,(H,17,19)(H,16,18,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.00E+3n/an/an/an/an/an/a



Piramal Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of HIF1alpha in human U251 cells under normoxic condition by luciferase reporter gene assay


Bioorg Med Chem Lett 20: 6426-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.083
BindingDB Entry DOI: 10.7270/Q2HX1CXM
More data for this
Ligand-Target Pair