BDBM50330574 1-(3-amino-6-(3-ethylthiophen-2-yl)pyrazin-2-yl)piperidine-4-carboxylic acid::CHEMBL1277019

SMILES CCc1ccsc1-c1cnc(N)c(n1)N1CCC(CC1)C(O)=O

InChI Key InChIKey=SXVAXEOOBRDRSC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50330574   

TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50330574(1-(3-amino-6-(3-ethylthiophen-2-yl)pyrazin-2-yl)pi...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of NEK2 by microfluidic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50330574(1-(3-amino-6-(3-ethylthiophen-2-yl)pyrazin-2-yl)pi...)
Affinity DataIC50:  720nMAssay Description:Inhibition of NEK2 autophosphorylation after 2 hrs by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50330574(1-(3-amino-6-(3-ethylthiophen-2-yl)pyrazin-2-yl)pi...)
Affinity DataIC50:  8.50E+3nMT: 2°CAssay Description:Inhibition of PLK1 after 75 mins at room temperature by caliper methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50330574(1-(3-amino-6-(3-ethylthiophen-2-yl)pyrazin-2-yl)pi...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of NEK2 assessed as inhibition of substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50330574(1-(3-amino-6-(3-ethylthiophen-2-yl)pyrazin-2-yl)pi...)
Affinity DataIC50:  2.25E+4nMT: 2°CAssay Description:Inhibition of NEK1 after 1 hr at room temperature by caliper methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50330574(1-(3-amino-6-(3-ethylthiophen-2-yl)pyrazin-2-yl)pi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed