BDBM50331066 6-chloro-5,7-dimethyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid::CHEMBL1288771

SMILES Cc1cc2OC(C(=Cc2c(C)c1Cl)C(O)=O)C(F)(F)F

InChI Key InChIKey=UNEVTVWOSGJGLU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50331066   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331066(6-chloro-5,7-dimethyl-2-(trifluoromethyl)-2H-chrom...)
Affinity DataIC50:  2.98E+4nMAssay Description:Inhibition of human COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331066(6-chloro-5,7-dimethyl-2-(trifluoromethyl)-2H-chrom...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant COX1 pre-incubated for 15 mins before fluorometric substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331066(6-chloro-5,7-dimethyl-2-(trifluoromethyl)-2H-chrom...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331066(6-chloro-5,7-dimethyl-2-(trifluoromethyl)-2H-chrom...)
Affinity DataIC50:  69nMAssay Description:Inhibition of human recombinant COX2 pre-incubated for 15 mins before fluorometric substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331066(6-chloro-5,7-dimethyl-2-(trifluoromethyl)-2H-chrom...)
Affinity DataIC50:  54nMAssay Description:Inhibition of human recombinant COX2 pre-incubated for 15 mins before fluorometric substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed