BDBM50331094 4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide::4-(3-chloro-4-(N'-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide::CHEMBL1289601::E-7080::Lenvatinib mesilate::Lenvima::US11912663, Compound Lenvatinib::US12071408, Example Lenvatinib::lenvatinib

SMILES: COc1cc2c(cc1C(=O)N)c(ccn2)Oc3ccc(c(c3)Cl)NC(=O)NC4CC4

InChI Key: InChIKey=WOSKHXYHFSIKNG-UHFFFAOYSA-N

Data: 4 KI  39 IC50  2 Kd

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 47 hits for monomerid = 50331094   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 3 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 3 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
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Ferrochelatase, mitochondrial [R115L] (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 1 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Vascular endothelial growth factor receptor 2 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 2 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 4 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	311	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 3 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 4 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Hepatocyte growth factor receptor (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 5A, mitochondrial (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		133	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 2 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 1 (Human)	BDBM50331094 (4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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