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BDBM50331378 CHEMBL1290613::N-((3R,4R)-4-(2'-fluorobiphenyl-4-yl)-1-methylpyrrolidin-3-yl)propane-2-sulfonamide

SMILES: CC(C)S(=O)(=O)N[C@H]1CN(C)C[C@@H]1c1ccc(cc1)-c1ccccc1F

InChI Key: InChIKey=SCDQHFURTSHURW-QUCCMNQESA-N

Data: 1 EC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331378   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GRIA2


(Homo sapiens (Human))
BDBM50331378
PNG
(CHEMBL1290613 | N-((3R,4R)-4-(2'-fluorobiphenyl-4-...)
Show SMILES CC(C)S(=O)(=O)N[C@H]1CN(C)C[C@@H]1c1ccc(cc1)-c1ccccc1F
Show InChI InChI=1S/C20H25FN2O2S/c1-14(2)26(24,25)22-20-13-23(3)12-18(20)16-10-8-15(9-11-16)17-6-4-5-7-19(17)21/h4-11,14,18,20,22H,12-13H2,1-3H3/t18-,20+/m1/s1
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Similars

Article
PubMed
n/an/an/an/a 2.50E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Positive modulation of human GluA2 flip receptor by FLIPR assay


Bioorg Med Chem Lett 20: 7116-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.062
BindingDB Entry DOI: 10.7270/Q2WQ042G
More data for this
Ligand-Target Pair