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BDBM50331819 6-[(1,1-Dioxo-tetrahydro-1lambda*6*-thiophen-3-ylmethyl)-amino]-9-fluoro-2H-benzo[c][1,6]naphthyridin-1-one::CHEMBL1290423

SMILES: Fc1ccc2c(NCC3CCS(=O)(=O)C3)nc3cc[nH]c(=O)c3c2c1

InChI Key: InChIKey=YJQUADKQWWERLA-UHFFFAOYSA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331819   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50331819
PNG
(6-[(1,1-Dioxo-tetrahydro-1lambda*6*-thiophen-3-ylm...)
Show SMILES Fc1ccc2c(NCC3CCS(=O)(=O)C3)nc3cc[nH]c(=O)c3c2c1
Show InChI InChI=1S/C17H16FN3O3S/c18-11-1-2-12-13(7-11)15-14(3-5-19-17(15)22)21-16(12)20-8-10-4-6-25(23,24)9-10/h1-3,5,7,10H,4,6,8-9H2,(H,19,22)(H,20,21)
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n/an/a 512n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of JAK2 in cell-free system


Bioorg Med Chem Lett 20: 7421-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.031
BindingDB Entry DOI: 10.7270/Q2SQ90MG
More data for this
Ligand-Target Pair