BDBM50332074 CHEMBL1287975::N-(2-(1,3-dimethyl-1H-1,2,4-triazol-5-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 3

SMILES Cc1nc(-c2sccc2NC(=O)Cc2cccc3ccccc23)n(C)n1

InChI Key InChIKey=GMDHUVZYMRKGIE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50332074   

TargetMitogen-activated protein kinase 10(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM50332074(N-(2-(1,3-dimethyl-1H-1,2,4-triazol-5-yl)thiophen-...)
Affinity DataIC50: 1.00E+4nMAssay Description:(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 8(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM50332074(N-(2-(1,3-dimethyl-1H-1,2,4-triazol-5-yl)thiophen-...)
Affinity DataIC50: 1.00E+4nMAssay Description:(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 8(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM50332074(N-(2-(1,3-dimethyl-1H-1,2,4-triazol-5-yl)thiophen-...)
Affinity DataIC50: 3.03E+4nMAssay Description:Inhibition of recombinant JNK1 after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM50332074(N-(2-(1,3-dimethyl-1H-1,2,4-triazol-5-yl)thiophen-...)
Affinity DataIC50: 3.15E+4nMAssay Description:Inhibition of recombinant JNK3 after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50332074(N-(2-(1,3-dimethyl-1H-1,2,4-triazol-5-yl)thiophen-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant JNK2 after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed