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BDBM50332158 (S)-4-(piperidin-3-ylamino)-2-(quinolin-3-yl)thieno[3,2-c]pyridine-7-carboxamide::CHEMBL1288251

SMILES: NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(sc12)-c1cnc2ccccc2c1

InChI Key: InChIKey=YZRGBLHMCIVFAS-GGYSOQFKNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50332158   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50332158
PNG
((S)-4-(piperidin-3-ylamino)-2-(quinolin-3-yl)thien...)
Show SMILES NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(sc12)-c1cnc2ccccc2c1
Show InChI InChI=1/C22H21N5OS/c23-21(28)17-12-26-22(27-15-5-3-7-24-11-15)16-9-19(29-20(16)17)14-8-13-4-1-2-6-18(13)25-10-14/h1-2,4,6,8-10,12,15,24H,3,5,7,11H2,(H2,23,28)(H,26,27)/t15-/s2
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Similars

Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation counting


Bioorg Med Chem Lett 20: 7216-21 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.105
BindingDB Entry DOI: 10.7270/Q2QV3MR6
More data for this
Ligand-Target Pair