BindingDB PrimarySearch

BDBM50332294 CHEMBL1287853::N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide::US10112907, Example 00018::US10730860, TABLE 1.3::US10766894, Compound TABLE 1.3::US11203595, TABLE 1.3::US11384069, Example T-5::US20240140952, Compound Fedratinib

SMILES: Cc1cnc(nc1Nc2cccc(c2)S(=O)(=O)NC(C)(C)C)Nc3ccc(cc3)OCCN4CCCC4

InChI Key: InChIKey=JOOXLOJCABQBSG-UHFFFAOYSA-N

Data: 3 KI 66 IC50 454 Kd

PDB links: 5 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 565 hits for monomerid = 50332294
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	n/a
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Tyrosine-protein kinase JAK2 [808-1132] (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [811-1124] (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	7.5	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [888-1187] (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	310	n/a	n/a	n/a	n/a	7.5	n/a
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Bromodomain-containing protein 4 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [811-1124] (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [888-1187] (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.08	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [V617F] (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.05	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.16	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [V617F] (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.06	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Tyrosine-protein kinase JAK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.89	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [V617F] (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.69	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Tyrosine-protein kinase JAK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.06	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [V617F] (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.78	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.24	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [V617F] (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.05	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.47	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [V617F] (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.55	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	15.6	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	976	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	178	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-G-associated kinase (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1/Tyrosine-protein kinase JAK2/Tyrosine-protein kinase JAK3 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
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AP2-associated protein kinase 1 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	169	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek1 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek3 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Serine/threonine-protein kinase Nek4 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase Nek5 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	570	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase Nek6 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Serine/threonine-protein kinase Nek7 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Serine/threonine-protein kinase Nek9 (Human)	BDBM50332294 (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a
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