BindingDB logo
myBDB logout

BDBM50332653 5-methyl-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole-3,4-dicarboxamide::CHEMBL1631086

SMILES: Cc1c(C(N)=O)c(nn1-c1cccc(c1)-c1ccccc1OC(F)(F)F)C(N)=O

InChI Key: InChIKey=BKGRPPQRGSQIIQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50332653   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50332653
PNG
(5-methyl-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H...)
Show SMILES Cc1c(C(N)=O)c(nn1-c1cccc(c1)-c1ccccc1OC(F)(F)F)C(N)=O
Show InChI InChI=1S/C19H15F3N4O3/c1-10-15(17(23)27)16(18(24)28)25-26(10)12-6-4-5-11(9-12)13-7-2-3-8-14(13)29-19(20,21)22/h2-9H,1H3,(H2,23,27)(H2,24,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 185n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.7 by VIPR assay


Bioorg Med Chem Lett 20: 7479-82 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.017
BindingDB Entry DOI: 10.7270/Q2MW2HDH
More data for this
Ligand-Target Pair