BDBM50333000 4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one::CHEMBL1629865

SMILES Cc1cc(ccn1)-c1cccc(c1)C1=Nc2ccc(cc2NC(=O)C1)C(F)(F)F

InChI Key InChIKey=DFWDFOZNVALGES-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50333000   

TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50333000(4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromet...)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50333000(4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromet...)
Affinity DataIC50:  36nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50333000(4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromet...)
Affinity DataIC50:  25nMAssay Description:Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50333000(4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromet...)
Affinity DataIC50:  18nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed