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BDBM50333602 4-(Benzyloxy)-1-{4-[2-(diethylamino)ethoxy]phenyl}-pyridin-2(1H)-one::CHEMBL1642485

SMILES: CCN(CC)CCOc1ccc(cc1)-n1ccc(OCc2ccccc2)cc1=O

InChI Key: InChIKey=BZUVXLPHVGFEJA-UHFFFAOYSA-N

Data: 3 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50333602   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50333602
PNG
(4-(Benzyloxy)-1-{4-[2-(diethylamino)ethoxy]phenyl}...)
Show SMILES CCN(CC)CCOc1ccc(cc1)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C24H28N2O3/c1-3-25(4-2)16-17-28-22-12-10-21(11-13-22)26-15-14-23(18-24(26)27)29-19-20-8-6-5-7-9-20/h5-15,18H,3-4,16-17,19H2,1-2H3
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Article
PubMed
n/an/a 6.60n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay


Bioorg Med Chem 19: 883-93 (2011)


Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50333602
PNG
(4-(Benzyloxy)-1-{4-[2-(diethylamino)ethoxy]phenyl}...)
Show SMILES CCN(CC)CCOc1ccc(cc1)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C24H28N2O3/c1-3-25(4-2)16-17-28-22-12-10-21(11-13-22)26-15-14-23(18-24(26)27)29-19-20-8-6-5-7-9-20/h5-15,18H,3-4,16-17,19H2,1-2H3
PDB
MMDB

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Article
PubMed
n/an/a 9.80n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanes...


Bioorg Med Chem 19: 883-93 (2011)


Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50333602
PNG
(4-(Benzyloxy)-1-{4-[2-(diethylamino)ethoxy]phenyl}...)
Show SMILES CCN(CC)CCOc1ccc(cc1)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C24H28N2O3/c1-3-25(4-2)16-17-28-22-12-10-21(11-13-22)26-15-14-23(18-24(26)27)29-19-20-8-6-5-7-9-20/h5-15,18H,3-4,16-17,19H2,1-2H3
Reactome pathway
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PC cid
PC sid
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Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced intracellular calcium release by FLIPR assay


Bioorg Med Chem 19: 883-93 (2011)


Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT
More data for this
Ligand-Target Pair