BDBM50333973 CHEMBL1644606::exo-3'-((1R,5S)-8-azabicyclo[3.2.1]octan-3-yloxy)biphenyl-4-carbonitrile

SMILES N#Cc1ccc(cc1)-c1cccc(O[C@H]2C[C@@H]3CC[C@H](C2)N3)c1

InChI Key InChIKey=RGCRPWWXLBCYBL-OPVJXMOQSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50333973   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333973(CHEMBL1644606 | exo-3'-((1R,5S)-8-azabicyclo[3.2.1...)
Affinity DataIC50:  60nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333973(CHEMBL1644606 | exo-3'-((1R,5S)-8-azabicyclo[3.2.1...)
Affinity DataIC50:  173nMAssay Description:Inhibition of [3H]dopamine reuptake at DAT expressed in HEK293 cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333973(CHEMBL1644606 | exo-3'-((1R,5S)-8-azabicyclo[3.2.1...)
Affinity DataIC50:  105nMAssay Description:Inhibition of [3H]serotonin reuptake at SERT expressed in HEK293 cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed