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BDBM50334749 CHEMBL1642854::N1-(3-(Naphthalen-1-ylsulfonyl)-1H-indazol-6-yl)ethane-1,2-diamine HCl

SMILES: NCCNc1ccc2c(n[nH]c2c1)S(=O)(=O)c1cccc2ccccc12

InChI Key: InChIKey=QXPWRAXEWDBKHX-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50334749   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334749
PNG
(CHEMBL1642854 | N1-(3-(Naphthalen-1-ylsulfonyl)-1H...)
Show SMILES NCCNc1ccc2c(n[nH]c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C19H18N4O2S/c20-10-11-21-14-8-9-16-17(12-14)22-23-19(16)26(24,25)18-7-3-5-13-4-1-2-6-15(13)18/h1-9,12,21H,10-11,20H2,(H,22,23)
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KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
17n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334749
PNG
(CHEMBL1642854 | N1-(3-(Naphthalen-1-ylsulfonyl)-1H...)
Show SMILES NCCNc1ccc2c(n[nH]c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C19H18N4O2S/c20-10-11-21-14-8-9-16-17(12-14)22-23-19(16)26(24,25)18-7-3-5-13-4-1-2-6-15(13)18/h1-9,12,21H,10-11,20H2,(H,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 87n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at cloned human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5HT-induced cyclic AMP formation


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair