BDBM50335145 4-Chloro-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyranosyl)-1Hindole::CHEMBL1650501

SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12

InChI Key InChIKey=ZMVJQRPQBABDLO-CWKRKGSWSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50335145   

TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50335145(4-Chloro-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyr...)
Affinity DataEC50:  203nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50335145(4-Chloro-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyr...)
Affinity DataEC50:  488nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50335145(4-Chloro-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyr...)
Affinity DataEC50:  209nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50335145(4-Chloro-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyr...)
Affinity DataEC50:  364nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50335145(4-Chloro-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyr...)
Affinity DataEC50:  161nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50335145(4-Chloro-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyr...)
Affinity DataEC50:  205nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed