BDBM50335158 3-[7-Fluoro-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-aza-spiro[4.5]dec-2-ene::CHEMBL1650521

SMILES Fc1cc(cc2[nH]c(nc12)C1=NOC2(C1)CCCCC2)-c1ccccc1C(F)(F)F

InChI Key InChIKey=HCSUJSYTOOHVBD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50335158   

TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335158(3-[7-Fluoro-5-(2-trifluoromethylphenyl)-1H-benzimi...)
Affinity DataIC50:  2.20nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335158(3-[7-Fluoro-5-(2-trifluoromethylphenyl)-1H-benzimi...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes after 15 misMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed