BDBM50335253 4-Chloro-3'-((2-cyclopentyl-1-oxoisoindolin-5-yloxy)methyl)-biphenyl-3-carboxylic Acid::CHEMBL1651208

SMILES OC(=O)c1cc(ccc1Cl)-c1cccc(COc2ccc3C(=O)N(Cc3c2)C2CCCC2)c1

InChI Key InChIKey=DWTYHCYVKJONSP-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50335253   

TargetHistamine H1 receptor(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335253(4-Chloro-3'-((2-cyclopentyl-1-oxoisoindolin-5-ylox...)
Affinity DataIC50:  8.15E+3nMAssay Description:Inhibition of radioligand binding to human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335253(4-Chloro-3'-((2-cyclopentyl-1-oxoisoindolin-5-ylox...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335253(4-Chloro-3'-((2-cyclopentyl-1-oxoisoindolin-5-ylox...)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK-293 cells assessed as thaillium flux through GIRK channelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335253(4-Chloro-3'-((2-cyclopentyl-1-oxoisoindolin-5-ylox...)
Affinity DataIC50:  8.15E+3nMAssay Description:Inhibition of radioligand binding to human adrenergic alpha1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335253(4-Chloro-3'-((2-cyclopentyl-1-oxoisoindolin-5-ylox...)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335253(4-Chloro-3'-((2-cyclopentyl-1-oxoisoindolin-5-ylox...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of radioligand binding to human adrenergic alpha1d receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed