BDBM50335377 CHEMBL1651534::N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxamide

SMILES O=C(Nc1cccnn1)N1CCC(=Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1

InChI Key InChIKey=ZZFDLTUYLGIZQH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50335377   

TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335377BDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human transmembrane domain deficient FFAH expressed in Escherichia coli using AAMCA as substrate incubated for 1 min measured for 50 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Advinus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335377BDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of rat FFAH expressed in Escherichia coli using AAMCA as substrate incubated for 1 min measured for 50 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335377BDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of His-tagged human FAAH N-terminal transmembrane-deleted truncated form expressed in Escherichia coli preincubated for 60 mins before ole...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335377BDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of human FAAH assessed as kinact/Ki ratio incubated for 60 min in presence of glutamate dehydrogenase by 384-well format microplate reader...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Advinus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335377BDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 7.40nMAssay Description:Irreversible inhibition of His-tagged rat FAAH N-terminal transmembrane-deleted truncated form expressed in Escherichia coli preincubated for 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335377BDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of rat FAAH assessed as kinact/Ki ratio incubated for 60 min in presence of glutamate dehydrogenase by 384-well format microplate reader a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335377BDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human FAAH assessed as kinact/Ki ratio incubated for 30 min in presence of glutamate dehydrogenase by 384-well format microplate reader...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFatty-acid amide hydrolase 1(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335377BDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 11nMAssay Description:Inhibition of rat FAAH assessed as kinact/Ki ratio incubated for 30 min in presence of glutamate dehydrogenase by 384-well format microplate reader a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFatty-acid amide hydrolase 1(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335377BDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 27nMAssay Description:Inhibition of rat FAAH assessed as kinact/Ki ratio incubated for 15 min in presence of glutamate dehydrogenase by 384-well format microplate reader a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335377BDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 32nMAssay Description:Inhibition of human FAAH assessed as kinact/Ki ratio incubated for 15 min in presence of glutamate dehydrogenase by 384-well format microplate reader...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFatty-acid amide hydrolase 1(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335377BDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 43nMAssay Description:Inhibition of rat FAAH assessed as kinact/Ki ratio incubated for 1 min in presence of glutamate dehydrogenase by 384-well format microplate reader as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335377BDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human FAAH assessed as kinact/Ki ratio incubated for 1 min in presence of glutamate dehydrogenase by 384-well format microplate reader ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335377BDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335377BDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 uisng testosterone substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335377BDBM50335377(N-Pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 uisng midazolam substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed