BDBM50335568 (1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-1-yl]piperidin-1-yl}cyclooctyl)methanol::CHEMBL1650848

SMILES CC1CN(CCN1)c1nc2ccccc2n1C1CCN(CC1)C1(CO)CCCCCCC1

InChI Key InChIKey=ZFBVHBCZNNALTI-UHFFFAOYSA-N

Data  4 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50335568   

TargetNociceptin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335568((1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335568((1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataKi:  275nMAssay Description:Displacement of [3H]enadoline from human KOP receptor expressed in HEK-293 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335568((1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataKi: >450nMAssay Description:Displacement of [3H]DAMGO from human MOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335568((1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataKi: >500nMAssay Description:Displacement of [3H]DPDPE from human DOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335568((1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataEC50:  38nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335568((1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataEC50:  1.77E+3nMAssay Description:Agonist activity at human MOP receptor expressed in CHO-K1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335568((1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-...)
Affinity DataEC50:  366nMAssay Description:Agonist activity at human KOP receptor expressed in HEK-293 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed