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BDBM50335671 4-fluoro-2-(4-((3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-ylamino)quinazolin-2-yl)phenol::CHEMBL1650117

SMILES: CC(C)(O)[C@@H]1CNC[C@H]1Nc1nc(nc2ccccc12)-c1cc(F)ccc1O

InChI Key: InChIKey=CEIIDGPSFYGDIQ-NVXWUHKLSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50335671   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase CHK2


(Homo sapiens (Human))
BDBM50335671
PNG
(4-fluoro-2-(4-((3S,4R)-4-(2-hydroxypropan-2-yl)pyr...)
Show SMILES CC(C)(O)[C@@H]1CNC[C@H]1Nc1nc(nc2ccccc12)-c1cc(F)ccc1O
Show InChI InChI=1S/C21H23FN4O2/c1-21(2,28)15-10-23-11-17(15)25-19-13-5-3-4-6-16(13)24-20(26-19)14-9-12(22)7-8-18(14)27/h3-9,15,17,23,27-28H,10-11H2,1-2H3,(H,24,25,26)/t15-,17-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 21n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK2 by DELFIA assay


J Med Chem 54: 580-90 (2011)


Article DOI: 10.1021/jm101150b
BindingDB Entry DOI: 10.7270/Q2DF6RHX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50335671
PNG
(4-fluoro-2-(4-((3S,4R)-4-(2-hydroxypropan-2-yl)pyr...)
Show SMILES CC(C)(O)[C@@H]1CNC[C@H]1Nc1nc(nc2ccccc12)-c1cc(F)ccc1O
Show InChI InChI=1S/C21H23FN4O2/c1-21(2,28)15-10-23-11-17(15)25-19-13-5-3-4-6-16(13)24-20(26-19)14-9-12(22)7-8-18(14)27/h3-9,15,17,23,27-28H,10-11H2,1-2H3,(H,24,25,26)/t15-,17-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of CHK1 by DELFIA assay


J Med Chem 54: 580-90 (2011)


Article DOI: 10.1021/jm101150b
BindingDB Entry DOI: 10.7270/Q2DF6RHX
More data for this
Ligand-Target Pair