BDBM50335987 2-chloro-N-(1-(3-methyl-4-(6-oxo-5,9-bis(2,2,2-trifluoroethoxy)-6H-pyrrolo[3,4-g]quinolin-7(8H)-yl)benzyl)cyclopropylcarbamoyl)benzenesulfonamide::CHEMBL1669011

SMILES Cc1cc(CC2(CC2)NC(=O)NS(=O)(=O)c2ccccc2Cl)ccc1N1Cc2c(C1=O)c(OCC(F)(F)F)c1cccnc1c2OCC(F)(F)F

InChI Key InChIKey=LKOISZAXLYFGBX-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50335987   

TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50335987(2-chloro-N-(1-(3-methyl-4-(6-oxo-5,9-bis(2,2,2-tri...)
Affinity DataKi:  0.480nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50335987(2-chloro-N-(1-(3-methyl-4-(6-oxo-5,9-bis(2,2,2-tri...)
Affinity DataKi:  14nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay in pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50335987(2-chloro-N-(1-(3-methyl-4-(6-oxo-5,9-bis(2,2,2-tri...)
Affinity DataIC50:  48nMAssay Description:Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50335987(2-chloro-N-(1-(3-methyl-4-(6-oxo-5,9-bis(2,2,2-tri...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed