BDBM50336041 1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile::CHEMBL1669278

SMILES Cn1cnc2c(nc(cc12)-c1ccc(OCCC2CCN(Cc3ncco3)CC2)c(c1)C(F)(F)F)C#N

InChI Key InChIKey=IKBUAFVMVGRIRN-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50336041   

TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336041(1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4...)
Affinity DataIC50:  39nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as accumulation of lip10 by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Mus musculus (Mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336041(1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of mouse cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336041(1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin VMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336041(1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336041(1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336041(1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4...)
Affinity DataIC50:  708nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336041(1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed