BDBM50336491 3-Hydroxy-benzoic acid::3-Hydroxybenzoate::3-Hydroxybenzoate, II::3-hydroxybenzoic acid::CHEMBL65369

SMILES OC(=O)c1cccc(O)c1

InChI Key InChIKey=IJFXRHURBJZNAO-UHFFFAOYSA-N

Data  7 KI  1 IC50  3 Kd  2 EC50

PDB links: 13 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50336491   

TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Calgary

Curated by ChEMBL
LigandPNGBDBM50336491(3-Hydroxy-benzoic acid | 3-Hydroxybenzoate | 3-Hyd...)
Affinity DataKi:  600nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University Of Calgary

Curated by ChEMBL
LigandPNGBDBM50336491(3-Hydroxy-benzoic acid | 3-Hydroxybenzoate | 3-Hyd...)
Affinity DataKi:  2.37E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 6(Homo sapiens (Human))
Gumushane University

Curated by ChEMBL
LigandPNGBDBM50336491(3-Hydroxy-benzoic acid | 3-Hydroxybenzoate | 3-Hyd...)
Affinity DataKi:  3.17E+3nMAssay Description:Inhibition of human CA6 using 4-nitrophenylacetate substrate by esterase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Calgary

Curated by ChEMBL
LigandPNGBDBM50336491(3-Hydroxy-benzoic acid | 3-Hydroxybenzoate | 3-Hyd...)
Affinity DataKi:  3.53E+3nMAssay Description:Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Calgary

Curated by ChEMBL
LigandPNGBDBM50336491(3-Hydroxy-benzoic acid | 3-Hydroxybenzoate | 3-Hyd...)
Affinity DataKi:  4.53E+3nMAssay Description:Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Dicentrarchus labrax)
Gumushane University

Curated by ChEMBL
LigandPNGBDBM50336491(3-Hydroxy-benzoic acid | 3-Hydroxybenzoate | 3-Hyd...)
Affinity DataKi:  9.83E+4nMAssay Description:Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl 4-hydroxylase subunit alpha-1(Gallus gallus (Chicken))
University Of Oulu

LigandPNGBDBM50336491(3-Hydroxy-benzoic acid | 3-Hydroxybenzoate | 3-Hyd...)
Affinity DataKi: >2.00E+7nMAssay Description:Inhibition assay using procollagen-prolin, 2-oxoglutarate 4-dioxygenase.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProbable salicylate monooxygenase [Y105F](Rhodococcus jostii RHA1)
Wageningen University

LigandPNGBDBM50336491(3-Hydroxy-benzoic acid | 3-Hydroxybenzoate | 3-Hyd...)
Affinity DataKd:  6.44E+5nMpH: 8.0Assay Description:The interaction of 3HB6H (25 uM) with substrate analogs was studied in 50 mM Tris-SO4 (pH 8.0). Dissociation constants (Kd) of enzyme-substrate compl...More data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336491(3-Hydroxy-benzoic acid | 3-Hydroxybenzoate | 3-Hyd...)
Affinity DataEC50:  2.15E+5nMAssay Description:Agonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable salicylate monooxygenase(Rhodococcus jostii RHA1)
Wageningen University

LigandPNGBDBM50336491(3-Hydroxy-benzoic acid | 3-Hydroxybenzoate | 3-Hyd...)
Affinity DataKd:  4.80E+4nMpH: 8.0Assay Description:The interaction of 3HB6H (25 uM) with substrate analogs was studied in 50 mM Tris-SO4 (pH 8.0). Dissociation constants (Kd) of enzyme-substrate compl...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50336491(3-Hydroxy-benzoic acid | 3-Hydroxybenzoate | 3-Hyd...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant PTP1B expressed in CHO cells assessed as p-nitorphenol production after 2 mins by microplate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336491(3-Hydroxy-benzoic acid | 3-Hydroxybenzoate | 3-Hyd...)
Affinity DataEC50:  1.84E+5nMAssay Description:Agonist activity at human recombinant GPR81 transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable salicylate monooxygenase [H213A](Rhodococcus jostii RHA1)
Wageningen University

LigandPNGBDBM50336491(3-Hydroxy-benzoic acid | 3-Hydroxybenzoate | 3-Hyd...)
Affinity DataKd:  6.10E+4nMpH: 8.0Assay Description:The interaction of 3HB6H (25 uM) with substrate analogs was studied in 50 mM Tris-SO4 (pH 8.0). Dissociation constants (Kd) of enzyme-substrate compl...More data for this Ligand-Target Pair