BDBM50336580 CHEMBL1672071::Isopropyl-3-(4-isopropylphenoxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile

SMILES CC(C)c1ccc(Oc2ccc3c4c(C#N)c(=O)nc4c4cccc2c34)cc1

InChI Key InChIKey=LQPUNUIMIHGZEE-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50336580   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50336580(CHEMBL1672071 | Isopropyl-3-(4-isopropylphenoxy)-8...)
Affinity DataKi:  99nMAssay Description:Displacement of FAM-Bid from human Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50336580(CHEMBL1672071 | Isopropyl-3-(4-isopropylphenoxy)-8...)
Affinity DataKi:  99nMAssay Description:Displacement of FAM-Bid peptide from human Mcl-1 after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50336580(CHEMBL1672071 | Isopropyl-3-(4-isopropylphenoxy)-8...)
Affinity DataKi:  252nMAssay Description:Displacement of FAM-Bid peptide from human recombinant Bcl2 after 30 mins by by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50336580(CHEMBL1672071 | Isopropyl-3-(4-isopropylphenoxy)-8...)
Affinity DataIC50:  321nMAssay Description:Binding affinity to cMcl-1 (residues 171 to 327) (unknown origin) by biotin-Bim displacement based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50336580(CHEMBL1672071 | Isopropyl-3-(4-isopropylphenoxy)-8...)
Affinity DataIC50:  650nMAssay Description:Binding affinity to N-terminal 8xHis tagged cBcl-XL (unknown origin) expressed in Escherichia coli BL21 (DE3) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50336580(CHEMBL1672071 | Isopropyl-3-(4-isopropylphenoxy)-8...)
Affinity DataIC50:  739nMAssay Description:Binding affinity to human Bcl-2 (unknown origin) by biotin-Bim displacement based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed