BDBM50336585 3-(4-methoxyphenylthio)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile::CHEMBL1672077

SMILES COc1ccc(Sc2ccc3c4c(C#N)c(=O)nc4c4cccc2c34)cc1

InChI Key InChIKey=UQVOXUZIGHRSOD-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50336585   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50336585(3-(4-methoxyphenylthio)-8-oxo-8H-acenaphtho[1,2-b]...)
Affinity DataKi:  151nMAssay Description:Displacement of FAM-Bid from human Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50336585(3-(4-methoxyphenylthio)-8-oxo-8H-acenaphtho[1,2-b]...)
Affinity DataIC50:  945nMAssay Description:Binding affinity to human Bcl-2 (unknown origin) by biotin-Bim displacement based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50336585(3-(4-methoxyphenylthio)-8-oxo-8H-acenaphtho[1,2-b]...)
Affinity DataIC50:  388nMAssay Description:Binding affinity to cMcl-1 (residues 171 to 327) (unknown origin) by biotin-Bim displacement based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50336585(3-(4-methoxyphenylthio)-8-oxo-8H-acenaphtho[1,2-b]...)
Affinity DataIC50:  833nMAssay Description:Binding affinity to N-terminal 8xHis tagged cBcl-XL (unknown origin) expressed in Escherichia coli BL21 (DE3) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed